Structure and Function

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In the below structure of the skin, which of the following is incorrect?

The stratum basale is the zone of localisation of hemidesmosomes

The stratum granulosum (2–5 cells) is responsible for the pathogenesis of atopic dermatitis

The straum spinosum contains the Odland bodies

The stratum lucidum is found in the palms and soles

Page 3

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In the below figure, which of the following is correct?

Structure marked 1 is the main APC of the epidermis

Structure 2 contains Birbeck granules

Structure 3 has dendrites

Topical or systemic glucocorticoids reduce the density of structure 3

Page 4

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Which of the following statement about desmosomes is incorrect?

They are also known as cadherins

They are composed of desmoglein–desmocollin

Dsg 1 is expressed in the basale layer

Dsg 3 is affected in staphylococcal infections

page 5

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The structure below is seen in the dermis, which of the following best describes this gland?

The secretion is usually clear and odorless

It is also referred to the ‘skin’s kidneys’

They are primarily affected in acne

They are androgen sensitive glands

page 6

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Which of the following best describes the role of filaggrin?

They are primarily localised to the S granulosum

They play a role in pemphigus

They are a major part of the skin barrier

They are implicated in atopic dermatitis

Page-12

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Which of the following best predicts skin color?

It is determined by the number of melanocytes

Indian skin is easily burnt

In black skin, the melanosomes are larger

Hydroquinone helps in enhancing pigment

Page 12

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Please see the diagram below and find the best possible answer.

Albinism is due to a defect in the step marked 3

PUVA therapy is useful in albinism

Freckles are due to a defect in step 2

Vitiligo is characterised by a defect in step 3

Page 13

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Structure and Function

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